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Effective management of hypertension often requires pharmacological intervention, which can involve either single pill combination therapy (SPC) or multiple pill combination therapy (MPC). However, the choice between SPC and MPC can be influenced by patient demographics, clinical characteristics, comorbid conditions and physician preferences.
This study aims to explore the prevalence of SPC versus MPC among hypertensive patients in a tertiary hospital and its associated factors.
A cross-sectional study using a validated questionnaire was conducted among the hypertensive patients aged 18 years and on antihypertensive medication(s) for at least six months attending various speciality clinics at Hospital Sultan Abdul Aziz Shah, Selangor.
The prevalence of patients using SPC was 27.9% (78/280).In univariate analysis, factors that were found to be associated with the use of SPC were presence of diabetes mellitus (p<0.001), presence of chronic kidney disease (p=0.033), physician’s own preference for SPC (p=0.027) and duration of hypertension (p=0.003) meanwhile in the multiple logistic regression analysis, the presence of chronic kidney disease, physician’s own preference for SPC and presence of diabetes mellitus were significantly associated with the use of SPC therapy (p<0.05).
The use of SPC is only 23.4%. Determinants of the use of SPC treatment were presence of diabetes mellitus, presence of chronic kidney disease and physician preferences for SPC. Hence, this study’s findings can be applied by healthcare providers who should consider these factors when prescribing hypertension treatments. Tailoring the treatment plan to the individual patient's needs and circumstances can enhance adherence and efficacy.
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